Fibrinogen

Template:STRUCTURE 1n73

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. It is this fibrin that forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin.

3D Structure of Fibrinogen3D Structure of Fibrinogen

Updated on 18-August-2014

Fibrinogen is composed of 2 copies each of 3 non-identical chains alpha, beta, gamma (, , ).

Fibrinogen α+β+γ chainsFibrinogen α+β+γ chains

3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2xnx, 2xny - hFba+hFbb+hFbg + M1 protein
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg – cow
1jy2 - cFba+cFbb+cFbg proteolytic fragment
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg

Fibrinogen α chainFibrinogen α chain

1fzd – hFba EC domain
1bbr – hFba+cε-thrombin
2jor – cFba – NMR
2baf – cFba

Fibrinogen β chainFibrinogen β chain

1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D

Fibrinogen γ chainFibrinogen γ chain

2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid – hFbg
3fib – hFbg C terminal
1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum
2hwl – hFbg peptide+prothrombin
2y7l – hFbg + agglutinin-like protein