Fibrinogen

Function Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing knobs A and B to form fibrin. The fibrin forms clots to prevent excessive bleeding from wounds sustained. Clotting factors, like factor XIII, are often linked to fibrin. 3D Printed Physical Model of Fibrinogen Shown below is a 3D printed physical model of Fibrinogen. The structure is shown as an alpha carbon backbone colored by chain, with the three chains of each copy of fibrinogen colored yellow, blue and purple. The MSOE Center for BioMolecular Modeling The MSOE Center for BioMolecular Modeling uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our Model Gallery. Structural insights Fibrinogen is composed of 2 copies each of 3 non-identical chains α, β, γ (, , ).

spinqualitylabelsall models Crystal structure of glycosylated fibrinogen fragment D. Subunit α (green and yellow), β (green and magenta), γ (pink and cyan) complex with the peptide ligand Gly-His-Arg-Pro-amide (red, wheat, blue, black) and Ca+2 ion (PDB code 1n73) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structure of Fibrinogen3D Structure of Fibrinogen

Updated on 28-July-2020

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• Fibrinogen α+β+γ chains
  • 3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
    
  • 3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
    
  • 2xnx, 2xny - hFba+hFbb+hFbg + M1 protein
    
  • 2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
    
  • 1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
    
  • 1jy3, 1deq – bFba+Fbb+Fbg – bovine
    
  • 1jy2 - bFba+Fbb+Fbg proteolytic fragment
    
  • 1m1j - cFba+Fbb+Fbg+peptide ligand – chicken
    
  • 1ei3 - cFba+Fbb+Fbg
    
  • 1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
    
• Fibrinogen α chain
  • 1fzd – hFba EC domain
    
  • 1bbr – hFba+cε-thrombin
    
  • 2jor – bFba – NMR
    
  • 2baf – bFba
    
• Fibrinogen β chain
  • 1fzf, 1fzg – hFb fragment double-D +peptide ligand
    
  • 1fze, 1fza, 1fzb – hFb fragment D
    
• Fibrinogen γ chain
  • 1fic, 1fid – hFbg
    
  • 3fib – hFbg C terminal
    
  • 2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
    
  • 2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+ antibody
    
  • 2fib, 3fib - hFbg+peptide ligand
    
  • 1fib – hFbg+Ca
    
  • 2hwl – hFbg peptide+prothrombin
    
  • 2y7l – hFbg + agglutinin-like protein
    
  • 1dug – Fbg C-terminal/glutathione S-transferase – Schistosoma japonicum