Calcium/Calmodulin-dependent protein kinase

Crystal Structure of membrane associated Ca2+/Calmodulin dependent protein kinase, 3mfr

Ca2+/Calmodulin dependent protein kinase (CaMK) phosphorylates Ser and Thr. It is regulated by Ca²⁺/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, i.e. crystal structure of human native membrane associated Ca²⁺/Calmodulin dependent protein kinase (3mfr).

3D Structures of Ca²⁺/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase

Updated on 17-August-2014

CaMKK – CaM kinase kinaseCaMKK – CaM kinase kinase

1iq5 – CeCaMK CBD+XlCaM – Xenopus laevis

CaMKI – specialized CaM kinaseCaMKI – specialized CaM kinase

1mxe – rCaMKI CBD+CaM – rat
1ckk – rCaMK CBD chain B+XlCaM
1a06 – rCaMK chain A

CASK – membrane-associated CaMKCASK – membrane-associated CaMK

3mfr – hCASK CBD – human
3mfs – hCASK+AMPPNP
3mft – hCASK+Mn
3c0g – hCASK kinase domain
3c0h - hCASK kinase domain+AMPPNP
3c0i - hCASK kinase domain+AMP
3mfu - hCASK+AMPPNP+Mn

DAPK – death-associated CaMKDAPK – death-associated CaMK

2x0g – hDAPK RD+AD+CaM
2cke – hDAPK+inhibitor

CaMKII – multifunctional CaM kinaseCaMKII – multifunctional CaM kinase

2vz6 - hCaMKII α chains A, B+ indirubin-E804
2zv2 – hCaMKII+STO-609
2wel - hCaMKII δ chain D+CaM
2w2c - hCaMKII δ chain ASD
2vn9 - hCaMKII δ chains A-B
3bhh - hCaMKII β chains A-D
2v7o - hCaMKII γ chain A
2ux0 - hCaMKII γ (mutant) chains A-F
2jam - hCaMKI γ+peptides
2jc6 - hCaMKII δ chains A,C
1hkx - mCaMKII α chains A-N ASD - mouse
3gp2 – cCaMKII δ chain B+CaM – chicken
3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
3kl8 – CeCaMKII (mutant)+inhibitor
3ksp – CaMKII ASD – Exiguobacterium sibiricum

CaMKIVCaMKIV

2w4o – hCaMKIV+inhibitor

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Alice Harmon, Jaime Prilusky

Calcium/Calmodulin-dependent protein kinase

Contents

3D Structures of Ca²⁺/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase

CaMKK – CaM kinase kinaseCaMKK – CaM kinase kinase

CaMKI – specialized CaM kinaseCaMKI – specialized CaM kinase

CASK – membrane-associated CaMKCASK – membrane-associated CaMK

DAPK – death-associated CaMKDAPK – death-associated CaMK

CaMKII – multifunctional CaM kinaseCaMKII – multifunctional CaM kinase

CaMKIVCaMKIV

See alsoSee also

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Calcium/Calmodulin-dependent protein kinase

3D Structures of Ca2+/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase

CaMKK – CaM kinase kinaseCaMKK – CaM kinase kinase

CaMKI – specialized CaM kinaseCaMKI – specialized CaM kinase

CASK – membrane-associated CaMKCASK – membrane-associated CaMK

DAPK – death-associated CaMKDAPK – death-associated CaMK

CaMKII – multifunctional CaM kinaseCaMKII – multifunctional CaM kinase

CaMKIVCaMKIV

See alsoSee also

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

3D Structures of Ca²⁺/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase