Tissue factor

<StructureSection load='1j9c' size='340' side='right' caption='Structure of human tissue factor complex with coagulation factor VIIa heavy chain and light chain and ihibitor (PDB code 2aer).' scene=>

FunctionFunction

Tissue factor (TF) is a high-affinity receptor for the blood coagulation factor VII. The TF/factor VII complex is responsible for the initiation of the coagulation protease cascade.

3D structures of tissue factor3D structures of tissue factor

Updated on 16-July-2014

1a21 – rTF extracellular domain – rabbit
2hft, 1boy, 1tfh – hTF extracellular domain – human

Tissue factor binary complexTissue factor binary complex

1dan, 1j9c, 1w0y – hTF extracellular domain + factor VIIA
1o5d – hTF extracellular domain (mutant) + factor VIIA
1ahw, 1jps, 1uj3 – hTF extracellular domain + antibody

Tissue factor ternary complex with coagulation factor VIIa and inhibitorTissue factor ternary complex with coagulation factor VIIa and inhibitor

1fak – hTF extracellular domain + factor VIIA + BPTI
1z6j, 1w2k, 2b7d, 2f9b, 2flb, 2a2q, 2aer, 2fir, 2aei, 2c4f, 2flr, 2ec9, 2zp0, 2zzu, 3th2, 4ibl – hTF extracellular domain + factor VIIA + inhibitor
1wqv, 1wss, 1wtg, 1wun, 1wv7, 2b8o, 2puq, 3ela, 2zwl, 3th3, 3th4 – hTF extracellular domain + factor VIIA + peptide mimetic inhibitor