Proteopedia

Succinate-semialdehyde dehydrogenase

Revision as of 12:04, 9 June 2014 by Michal Harel (talk | contribs)

<StructureSection load='3vz3' size='340' side='right' caption='Structure of succinate-semialdehyde dehydrogenase complex with NADPH and succinate semialdehyde (PDB code 3vz3).' scene=>

FunctionFunction

Succinate-semialdehyde dehydrogenase (SSD) catalyzes the conversion of succinate semialdehyde, NAD+ and water to succinate, NADH and H+. SSD participates in glutamate and butyrate metabolism.

DiseaseDisease

SSD deficiency.

RelevanceRelevance

Structural highlightsStructural highlights

3D structures of succinate-semialdehyde dehydrogenase3D structures of succinate-semialdehyde dehydrogenase

Updated on 09-June-2014

4it9, 3vz1 – SySSD - Synechococcus
3vz2 – SySSD (mutant)
3ifg, 3ifh – SSD – Burkholderia pseudomallei
3rh9 – SSD – Marinobacter aquaeolei
2w8n, 2w8o – hSSD - human
2w8p – hSSD (mutant)

Succinate-semialdehyde dehydrogenase complexes

2w8q – hSSD (mutant) + succinate
2w8r – hSSD (mutant) + ADP
4ita – SySSD + NADPH
4itb – SySSD + NADPH + succinic semialdehyde
3vz3 – SySSD (mutant) + NADPH + succinic semialdehyde
3jz4 – SSD + NADPH – Escherichia coli


ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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