NEDD8

Crystal Structure of NEDD8, 1ndd

NEDD8 is a ubiquitin-like protein in human. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase. In yeast the protein is called Rub1. The images at the left and at the right correspond to one representative NEDD8, i.e. the crystal structure of NEDD8 (1ndd). Cl and SO4 are shown as space filling objects.

3D Structures of NEDD83D Structures of NEDD8

Updated on 30-March-2014

NEDD8NEDD8

1ndd - hNEDD8 - human
2ko3 – hNEDD8 – NMR

NEDD8+ubiquitin-activating enzyme E1NEDD8+ubiquitin-activating enzyme E1

3gzn – hNEDD8+hE1 regulatory and catalytic subunits
3dbh, 3dbl, 3dbr - hNEDD8+hE1 regulatory and catalytic subunits (mutant)
2nvu - hNEDD8+hE1 regulatory subunit+MBP/E1 catalytic subunit+UBC12
1r4m - hNEDD8+hE1C+amyloid beta precursor protein
1r4n - hNEDD8+hE1C+amyloid beta precursor protein+ATP

NEDD8+other proteinsNEDD8+other proteins

3dqv – hNEDD8+CUL-5
2bkr – hNEDD8+NEDP1
1xt9 – hNEDD8+DEN1
4f8c – hNEDD8 + cycle inhibiting factor
4hcp – hNEDD8 + ATP/GTP binding protein

Rub1Rub1

1bt0 – Rub1 – Arabidopsis thaliana

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Alexander Berchansky, Jaime Prilusky, Michal Harel