NEDD8

NEDD8 is a ubiquitin-like protein in humans. It facilitates ubiquitin conjugation. It participates in the recruitment of E2 to the ubiquitin ligase complex. NEDD8 modifies the cullin subunits (CUL) of SCF ubiquitin E3 ligase. In yeast the protein is called Rub1. . Water molecules are shown as red spheres.

spinqualitylabelsall models Human NEDD8 complex with sulfate and Cl- (green) ions, 1ndd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of NEDD83D Structures of NEDD8

Updated on 17-November-2021

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• NEDD8
  • 1ndd - hNEDD8 - human
    
  • 2ko3 – hNEDD8 – NMR
    
• NEDD8+ubiquitin-activating enzyme E1
  • 3gzn – hNEDD8+hE1 regulatory and catalytic subunits
    
  • 3dbh, 3dbl, 3dbr - hNEDD8+hE1 regulatory and catalytic subunits (mutant)
    
  • 2nvu - hNEDD8+hE1 regulatory subunit+MBP/E1 catalytic subunit+UBC12
    
  • 1r4m - hNEDD8+hE1C+amyloid beta precursor protein
    
  • 1r4n - hNEDD8+hE1C+amyloid beta precursor protein+ATP
    
• NEDD8+other proteins
  • 3dqv – hNEDD8+CUL-5
    
  • 2bkr – hNEDD8+NEDP1
    
  • 1xt9 – hNEDD8+DEN1
    
  • 4f8c – hNEDD8 + cycle inhibiting factor
    
  • 4hcp – hNEDD8 + ATP/GTP binding protein
    
  • 4fbj – hNEDD8 + bacterial effector CIF
    
  • 4p5o – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + DCN1-like protein + UBC12
    
  • 7oni – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + ring-box protein – Cryo EM
    
  • 7b5n – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + polyubiquitin – Cryo EM
    
  • 7b5l – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + polyubiquitin + S-phase kinase-associated protein + CKS-1 – Cryo EM
    
  • 6ttu – hNEDD8 + cullin-1 + E3 ubiquitin-protein ligase + F-box/WD repeat containing protein + S-phase kinase-associated protein – Cryo EM
    
  • 6r7f – hNEDD8 in signalosome – Cryo EM
    
• Rub1
  • 1bt0 – Rub1 – Arabidopsis thaliana