4au7

The structure of the Suv4-20h2 ternary complex with histone H4The structure of the Suv4-20h2 ternary complex with histone H4

FunctionFunction

[SV422_MOUSE] Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).^[1]

About this StructureAbout this Structure

4au7 is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Southall SM, Cronin NB, Wilson JR. A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res. 2013 Sep 18. PMID:24049080 doi:10.1093/nar/gkt776

↑ Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62. Epub 2004 May 14. PMID:15145825 doi:http://dx.doi.org/10.1101/gad.300704

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OCA

[2] Southall SM, Cronin NB, Wilson JR. A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases. Nucleic Acids Res. 2013 Sep 18. PMID:24049080 doi:10.1093/nar/gkt776

[1] Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev. 2004 Jun 1;18(11):1251-62. Epub 2004 May 14. PMID:15145825 doi:http://dx.doi.org/10.1101/gad.300704

[1]

[xtra 1]