Histone methyltransferase

Function Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT. CxxC domain is a zinc finger domain. For SET7/9 see Histone Lysine Methyltransferase SET7/9. euchromatin histone methyltransferase dimethylates histone H3 at Lys 9 resulting in transcriptional repression. DOT1L histone methyltransferase methylates histone H3 at Lys 79 resulting in transcriptional repression. Relevance Inhibitors of the histone-lysine N-methyltransferase SMYD2 which represses the tumor-suppressing activities of p53 are studied as cancer therapy drugs. Disease Aberrant HMT plays a role in cancer, intellectual disability syndromes and regulation of tissue aging. Structural highlights Human inserted in a hydrophobic environment. Water molecules shown as red spheres 3D Structures of histone methyltransferase Histone methyltransferase 3D structures

spinqualitylabelsall models Human histone-lysine N-methyltrasferase (magenta) complex with methylated lysine histone H3 peptide (green) and S-adenosyl homocysteine (SAH) (PDB entry 1o9s) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image