Malate synthase

<StructureSection load='1n8w' size='350' side='right' caption='Structure of malate synthase complex with CoA, glyoxylate and Mg+2 ion (PDB entry 1n8w)' scene=>

Malate synthase (MS) catalyzes the reversible conversion of acetyl-CoA, glyoxylate and water to (S)-malate and CoA. MS participates in pyruvate, glyoxylate and dicarboxylate metabolism. There are 2 isozymes of MS. MS G is formed during growth on glycolate and MS A which metabolizes glyoxylate formed in the dissimilation of acetate.

3d structures of malate synthase3d structures of malate synthase

Malate synthase GMalate synthase G

1y8b, 2jqx – EcMS (mutant) – Escherichia coli - NMR
4ex4 – MS + Mg – Mycobacterium leprae

Malate synthase G binary complexMalate synthase G binary complex

1d8c – EcMS (mutant) + glyoxylate + Mg
1n8i – MtMS + glyoxylate + Mg – Mycobacterium tuberculosis
3s9i, 3s9z, 3sad, 3saz, 3sb0 – MtMS (mutant) + inhibitor + Mg

Malate synthase G ternary complexMalate synthase G ternary complex

1p7t – EcMS (mutant) + pyruvate + Mg + acetyl-CoA
1n8w – MtMS + glyoxylate + Mg + CoA
2gq3 – MtMS + malate + Mg + CoA