Histone methyltransferase

Template:STRUCTURE 3s7j

Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor. KHMT can be SET domain-containing or non-SET domain-containing. The SET domain contains the catalytic core of KHMT and targets the lysine tail region of KHMT.

3D Structures of histone methyltransferase3D Structures of histone methyltransferase

Updated on 28-November-2013

1nw3 – hHMT DOT1L – human

2igq – hHMT-1 C terminal

Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase

2j8a – KHMT SET1 RRM domain – yeast

3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT SET7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
3n71 - hKHMT Smyd1
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal

Histone-lysine N-methyltransferase complexesHistone-lysine N-methyltransferase complexes

3rib – hKHMT Smyd2 + SAH
1o9s - hKHMT SET7/9 Set domain + SAH + H3 peptide
2bqz - hKHMT SET7 Set domain + SAH + H4 peptide
1mt6 - hKHMT SET7/9 residues 58-337 + SAH
1n6a – hKHMT SET7/9 SET domain + SAM
1n6c – hKHMT SET7/9 residues 70-366 + SAM
1xqh - hKHMT SET7/9 SET domain + SAH + p53 peptide
2f69, 3m53 - hKHMT SET7/9 SZET domain + SAH + TAF10 peptide
3m54, 3m55, 3m56, 3m57, 3m58, 3m59, 3m5a - hKHMT SET7/9 SET domain (mutant) + SAH + TAF10 peptide
3cbm - hKHMT SET7/9 SET domain + SAM + estrogen receptor peptide
4e47, 4jds, 4jlg - hKHMT SET7/9 SET domain + SAM + inhibitor
3cbo - hKHMT SET7/9 SET domain + SAH + estrogen receptor peptide
3os5 - hKHMT SET7/9 SET domain + SAH + DNMT1 peptide
3cbp - hKHMT SET7/9 SET domain + sinefungin
3vuz, 3vv0 - hKHMT SET7/9 SET domain + deoxyadenosine derivative
3qxy, 3rc0 - hKHMT SETD6 SET domain + p65 peptide + SAM
3s7b - hKHMT Smyd2 + SAM + inhibitor

3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide

3s7j, 3tg4 - hKHMT Smyd2 + SAM
4l58 - hKHMT PHD-type zinc finger domain + H3 peptide
1peg - NcKHMT Dim-5 + SAH + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide
4au7 - KHMT + SAH + H4 peptide - mouse

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman