4ezt

Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)Crystal structure of the substrate binding domain of E.coli DnaK in complex with heliocin (residues 14 to 21)

FunctionFunction

[DNAK_ECOLI] Plays an essential role in the initiation of phage lambda DNA replication, where it acts in an ATP-dependent fashion with the DnaJ protein to release lambda O and P proteins from the preprimosomal complex. DnaK is also involved in chromosomal DNA replication, possibly through an analogous interaction with the DnaA protein. Also participates actively in the response to hyperosmotic shock.[HAMAP-Rule:MF_00332]

About this StructureAbout this Structure

4ezt is a 2 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Zahn M, Berthold N, Kieslich B, Knappe D, Hoffmann R, Strater N. Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J Mol Biol. 2013 Apr 2. pii: S0022-2836(13)00208-8. doi:, 10.1016/j.jmb.2013.03.041. PMID:23562829 doi:10.1016/j.jmb.2013.03.041

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Zahn M, Berthold N, Kieslich B, Knappe D, Hoffmann R, Strater N. Structural Studies on the Forward and Reverse Binding Modes of Peptides to the Chaperone DnaK. J Mol Biol. 2013 Apr 2. pii: S0022-2836(13)00208-8. doi:, 10.1016/j.jmb.2013.03.041. PMID:23562829 doi:10.1016/j.jmb.2013.03.041

[xtra 1]