Histone methyltransferase

Template:STRUCTURE 3s7j

Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.

3D Structures of histone methyltransferase3D Structures of histone methyltransferase

Updated February 2013

1nw3 – hHMT DOT1L – human

2igq – hHMT-1 C terminal

Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase

2j8a – KHMT SET1 RRM domain – yeast

3s8s – hKHMT SETD1A RRM domain
2r3a – hKHMT Suv39H2
3rq4 - hKHMT Suv420H2
3s8p - hKHMT Suv420H1
3mts - hKHMT Suv39H1 chromo domain
1h3i - hKHMT Set7/9 residues 52-344
2o8j - hKHMT H3K9 residues 913-1193
2lv9 - hKHMT Mll5 residues 109-188 - NMR
3n71 - hKHMT Smyd1
1ml9 – NcKHMT Dim-5 – Neurospora crassa
1n3j – PvKHMT – Paramecium bursaria chlorella virus
1u2z – yKHMT C terminal

Histone-lysine N-methyltransferase complexesHistone-lysine N-methyltransferase complexes

3rib – hKHMT Smyd2 + SAH
1o9s - hKHMT Set7/9 residues 52-344 + H3 peptide
2bqz - hKHMT Set7 residues 192-352 + H4 peptide
1mt6 - hKHMT Set7/9 residues 58-337 + SAH
2rfi, 3hna - hKHMT H3K9 catalytic domain + H3 peptide
3b95 - hKHMT ankyrin repeat domain + H3 peptide
3lqi, 3lqj - hKHMT Mll1 3rd Phd finger and bromodomain + H3 peptide
3s7b - hKHMT Smyd2 + SAM + inhibitor

3s7d, 3s7f, 3tg5 - hKHMT Smyd2 + SAH + p53 peptide

3s7j, 3tg4 - hKHMT Smyd2 + SAM
1peg - NcKHMT Dim-5 + H3 peptide
2g46 – PvKHMT + SAH + H3 peptide

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman