Prostaglandin D synthase

Template:STRUCTURE 1pd2 Prostaglandin D synthase (PGDS) catalyzes the reversible conversion of 9α-11α-epidoxy-15-hydroxyprosta-5,13-dienoate to 9α-15-dihydroxy-11-oxoprosta-5,13-dienoate. PGDS is believed to be a cause of baldness. Prostaglandin D2 synthase (PGD2S) catalyzes the conversion of prostaglandin H2 to prostaglandin D2 (PGD2). PGD2 functions as a neuromodulator and in smooth muscle contraction. PGD2S is a lipocalin-type enzyme which transports small hydrophobic molecules such as steroids. PGDS is a major constituent of cerebrospinal fluid. PGDS binds small lipophilic molecules like retinal and thyroid hormone. Hematopoietic PGDS is named also Glutathione S-transferase σ class. Glutathione is PGDS cofactor.

3D structures of prostaglandin D synthase3D structures of prostaglandin D synthase

Prostaglandin D synthase

See also Glutathione S-transferase σ class. 1pd2 – PGDS + glutathione – rat
1iyh, 1iyi - hPGDS + glutathione – human
1v40, 2cvd, 3ee2, 3kxo, 3vi5, 3vi7 - hPGDS + inhibitor + glutathione

Prostaglandin D2 synthase

Glutatione-dependent

2vcq, 2vcw, 2vcx, 2vcz, 2vd0, 2vd1 – hPGD2S + inhibitor + glutathione

Glutatione-independent

2e4j, 2rq0 - mPGD2S (mutant) – mouse – NMR
2ktd - mPGD2S (mutant) + substrate analog – NMR
2czt, 2czu – mPGD2S (mutant)
2wwp – hPGD2S
3o19, 3o22, 3o2y - hPGD2S (mutant) + oleate + palmitate