Plasmepsin

Crystal Strcture of the Plasmepsin, 3fns

Plasmepsin (Plm) is a hemoglobin-degrading enzyme produced by the plasmodium parasite. It is a potential target for anti-malaria drugs. It is an aspartic acid protease having 2 aspartic acid residues in the active site. Ten Plm isoforms are known which are named Plm I, II, etc and Histo-Aspartic Protease (HAP). ProPml II exhibits a large shift between its domains which renders the protease inactive. The images on the left and right correspond to one representative Plm structure, i.e. the Plasmepsin from Plasmodium falciparum (3fns).

3D Structures of Plasmepsin3D Structures of Plasmepsin

Update June 2011

HAPHAP

3fns – PfHAP - Plasmodium falciparum
3fnt – PfHAP + inhibitor pepstatin
3fnu – PfHAP + KNI-10006

Plm IPlm I

3qrv – PfPlm I residues 117-457
3qs1 - PfPlm I residues 117-457 + inhibitor

Plm IIPlm II

1lf4 – PfPlm II
3f9q – PfPlm II (mutant)
2r9b – PfPlm II + peptide inhibitor
1w6h, 2bju, 1lf2, 1lf3, 1lee, 2igx, 2igy – PfPlm II + inhibitor
1w6i, 1xdh, 1xe5, 1xe6, 1me6, 1sme – PfPlm II + pepstatin derivative
1m43 - PfPlm II (mutant) + pepstatin derivative

ProPlm IIProPlm II

1pfz - PfProPlm II
1miq – PvProPlm II – Plasmodium vivax
1qs8 - PvPlm + pepstatin derivative

Plm IVPlm IV

2anl – Plm IV + statine derivative – Plasmodium malariae
1ls5 - PfPlm IV + pepstatin derivative

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman