Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin ACrystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A

Structural highlights

1ls5 is a 4 chain structure with sequence from Plasmodium falciparum and Streptomyces argenteolus subsp. toyonakensis. This structure supersedes the now removed PDB entry 1jgf. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PLM4_PLAF7 During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).[UniProtKB:Q17SB3]

Evolutionary Conservation

 

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1ls5, resolution 2.80Å

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OCA