3ik3
AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based ResistanceAP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
Template:ABSTRACT PUBMED 19878872
About this StructureAbout this Structure
3ik3 is a 2 chain structure of Proto-oncogene tyrosine-protein kinase with sequence from Mus musculus. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ O'Hare T, Shakespeare WC, Zhu X, Eide CA, Rivera VM, Wang F, Adrian LT, Zhou T, Huang WS, Xu Q, Metcalf CA 3rd, Tyner JW, Loriaux MM, Corbin AS, Wardwell S, Ning Y, Keats JA, Wang Y, Sundaramoorthi R, Thomas M, Zhou D, Snodgrass J, Commodore L, Sawyer TK, Dalgarno DC, Deininger MW, Druker BJ, Clackson T. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. PMID:19878872 doi:10.1016/j.ccr.2009.09.028
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OCACategories:
- Pages with broken file links
- Mus musculus
- Non-specific protein-tyrosine kinase
- Zhou, T.
- Atp-binding
- Bcr-abl
- Cell adhesion
- Cml
- Cytoskeleton
- Drug resistance
- Inhibitor
- Kinase
- Lipoprotein
- Magnesium
- Manganese
- Metal-binding
- Mutation
- Myristate
- Nucleotide-binding
- Nucleus
- Phosphoprotein
- Proto-oncogene
- Sh2 domain
- Sh3 domain
- T315i
- Transferase