Transferrin receptor

Template:STRUCTURE 1suv

Transferrin receptor (TfR) imports iron into the cell by receptor-mediated endocytosis of transferrin-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin.

3D structures of transferrin receptor3D structures of transferrin receptor

1cx8 – hTfR ectodomain – human
1de4 - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin
1suv - hTfR ectodomain + transferrin
3s9l, 3s9m, 3s9n - hTfR ectodomain + transferrin N-lobe
2nsu - hTfR ectodomain in dog retrovirus – EM
3kas - hTfR ectodomain + Machupo virus GP1

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman