Transferrin receptor

Function Transferrin receptor (TfR) imports iron into the cell by receptor-mediated endocytosis of transferrin-iron complex. TfR is regulated by intracellular iron concentration. The amount of TfR expressed on the cell is proportional to the cell’s need for iron. The TfR has selective affinity for diferric-transferrin. The TfR-transferrin complex is internalized by the cell and iron is released to the cytosol. The TfR-apotransferrin complex returns to the extracellular surface where the apotransferrin dissociates and is replaced by diferric-transferrin. Relevance TfR is a potential determinant of iron loading in congenital anemias. Structural highlights (1suv). 3D structures of transferrin receptor Updated on 04-May-2025 Domains – apical 197-378; ectodomain 121-760 1cx8 – hTfR ectodomain – human 6y76, 8p0z - hTfR apical domain 1de4 - hTfR ectodomain + hemochromatosis protein + β-2-microglobulin 1suv, 6soy, 6soz - hTfR ectodomain + transferrin 6okd - hTfR ectodomain + TfR-binding cysteine-dense peptide 6d03, 6d04, 6d05 - hTfR ectodomain + transferrin – Cryo EM 6gsr, 6h5i - hTfR ectodomain + ferritin heavy chain – Cryo EM 6s9j - hTfR ectodomain + PRE-GP-C 3s9l, 3s9m, 3s9n - hTfR ectodomain + transferrin N-lobe 2nsu - hTfR ectodomain in dog retrovirus – Cryo EM 3kas - hTfR ectodomain + Machupo virus GP1 6wrv, 6wrw, 6wrx - hTfR ectodomain + synthetic protein 7zqs - hTfR + DNA – Cryo EM

spinqualitylabelsall models Human transferrin receptor ectodomain dimer (grey and green) complex with transferrin N-lobe (pink and yellow) and C-lobe (cyan and magenta) and carbonate, 1suv Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image