Histone methyltransferase
Histone methyltransferase (HMT) are histone-lysine N-methyltransferase (KHMT) and histone-arginine N-methyltransferase (RHMT) which catalyzes the transfer of methyl groups to lysine and arginine residues of histones. HMT use S-adenosyl methionine (SAM) or S-adenosyl homocysteine (SAH) as the methyl donor.
3D Structures of histone methyltransferase3D Structures of histone methyltransferase
1nw3 – hHMT DOT1L – human
2igq – hHMT-1 C terminal
Histone-lysine N-methyltransferaseHistone-lysine N-methyltransferase
2j8a – KHMT SET1 RRM domain – yeast
3s8s – hKHMT SETD1A RRM domain
3rib – hKHMT Smyd2 + SAH
3s7b - hKHMT Smyd2 + SAM + inhibitor