Pseudouridine synthase

tRNA pseudouridine synthase (PUS) catalyzes the conversion of tRNA uridine to tRNA pseudouridine. PUS are active in the ribosomal large subunit (Rlu) and ribosomal small subunit (Rsu).

3D Structures of tRNA pseudouridine synthase3D Structures of tRNA pseudouridine synthase

1dj0 – EcPUS I – Escherichia coli
1ze1 – TmPUS B – Thermotoga maritima
1ksk, 1ksl – EcPUS RsuA
1vio - PUS RsuA – Haemophilus influenzae
1xpi - EcPUS RluC catalytic domain
1v9k - EcPUS RluC C-terminal domain (mutant)
2ist - EcPUS RluD
1prz, 1qyu, 1v9f - EcPUS RluD catalytic domain
2olw - EcPUS RluE
2oml - EcPUS RluE catalytic domain
2gml - EcPUS RluF catalytic domain
1vs3 – PUS TruA – Thermus thermophilus
1sgv – PUS TruB – Mycobacterium tuberculosis
1si7, 1szw, 1sb7 - EcPUS TruD

===PUS complex with RNA===

1k8w – EcPUS B + stem-loop RNA
1zl3 - EcPUS B (mutant) + stem-loop RNA
2i82 – EcPUS RluA + RNA
3dh3 - EcPUS RluF + RNA
2nqp, 2nr0, 2nre – EcPUS TruA + Leu-tRNA
3hjw, 3lwo, 3lwp, 3lwq, 3lwr, 3lwv – PfPUS CBF5 + ribosome biogenesis protein Nop10 + ribosomal protein L7 + RNA – Pyrococcus furiosus
3mqk - PfPUS CBF5 + ribosome biogenesis protein Nop10 + small nuclear RNP Gar1-like protein + RNA
3hjy - PfPUS CBF5 + ribosome biogenesis protein NOP10 + RNA
1ze2 - TmPUS B + RNA
2ab4 - TmPUS B (mutant) + RNA
1r3e, 1r3f - EcPUS B + RNA

2aus – PUS B + ribosome biogenesis protein Nop10 – Pyrococcus abyssi