Matrix metalloproteinase

Matrix metalloproteinases (MMP) are Zinc-dependent endopeptidases. MMP degrades extracellular matrix proteins. MMPs are produced by 28 different genes and are classified according to their protein substrates. They are inhibited by proteases called tissue inhibitors of metalloproteinase (TIMP). The pro-MMP contains a pro-peptide which must be removed to render the MMP active.

3D structures of matrix metalloproteinase3D structures of matrix metalloproteinase

MMP1 interstitial collagenaseMMP1 interstitial collagenase

1su3 – pro-hMMP – human

MMP2 gelatinase-AMMP2 gelatinase-A

1qib - hMMP catalytic domain (mutant)
1rtg - hMMP hemopexin-like domain
1ks0 – hMMP first fibronectin type II domain – NMR
1cxw - hMMP second fibronectin type II domain – NMR
1j7m - hMMP third fibronectin type II domain (mutant) – NMR
1eak – pro-hMMP catalytic domain (mutant) + peptide inhibitor
1hov, 1eub - hMMP catalytic domain + inhibitor– NMR
1gxd – pro-hMMP (mutant) + TIMP-2

MMP3 stromelysin 1MMP3 stromelysin 1

1qia, 1qic, 1cqr, 1slm - hMMP catalytic domain
3ohl, 3oho, 1g49, 1ciz, 1b8y, 1caq, 1usn, 2usn, 1ums, 1umt – hMMP catalytic domain + inhibitor
1uea - hMMP catalytic domain + TIMP-1
1oo9 - hMMP catalytic domain + TIMP-1 N terminal
2jt5, 2jt6, 2jnp, 3usn, 1sln - hMMP catalytic domain + inhibitor – NMR

MMP7 matrilysinMMP7 matrilysin

2y6c, 2y6d – hMMP residues 95-298 + inhibitor

MMP8 neutrophil collagenaseMMP8 neutrophil collagenase

3dng, 3dpe, 3dpf, 1zp5, 1jh1, 1jj9, 1i76, 1a85, 1mmb – hMMP catalytic domain + inhibitor
1i73 - hMMP catalytic domain + peptide inhibitor

MMP9 gelatinase-BMMP9 gelatinase-B

1l6j - pro-hMMP
1gkc - hMMP catalytic domain + inhibitor
2ovx, 2ovz, 2ow0, 2ow1, 2ow2, 1gkd - hMMP catalytic domain (mutant) + inhibitor

MMP10 stromelysin 2MMP10 stromelysin 2

1q3a - hMMP catalytic domain (mutant)

MMP11 stromelysin 3MMP11 stromelysin 3

1hv5 - hMMP catalytic domain + inhibitor

MMP12 macrophageMMP12 macrophage

3ba0, 2oxu - hMMP
2krj, 2k9c - hMMP catalytic domain – NMR
1jk3 - hMMP catalytic domain
2poj - hMMP catalytic domain (mutant) - NMR
2jxy - hMMP hemopexin-like domain - NMR
3n2u, 3n2v, 2wo8, 2wo9, 2woa, 1utt, 1utz, 1ros – hMMP catalytic domain + inhibitor
3lk8, 3lik, 3lil, 3lir, 3ljg, 3nx7, 3lka, 3ehx, 3ehy, 3f15, 3f16, 3f17, 3f18, 3f19, 3f1a, 1y93, 1rmz, 1os2, 1os9 - hMMP catalytic domain (mutant) + inhibitor
2k2g, 2z2d - hMMP catalytic domain + inhibitor - NMR
2w0d, 1ycm, 1z3j - hMMP catalytic domain (mutant) + inhibitor - NMR

MMP13 collagenase 3MMP13 collagenase 3

1cxv - MMP catalytic domain - mouse
2yig, 3ljz, 3kec, 3kej, 3kek, 3kry, 3i7g, 3i7i, 3elm, 2pjt, 2ozr, 1xuc, 1xud, 1xur, 1you – hMMP catalytic domain + inhibitor

MMP14 Membrane T1MMP14 Membrane T1

3ma2 – hMMP residues 112-292 + TIMP-1 (mutant)
1buv, 1bqq - hMMP + TIMP-2
3c7x – hMMP hemopexin-like domain

MMP16 Membrane T3MMP16 Membrane T3

1rm8 - hMMP catalytic domain + inhibitor

MMP20 enamelysinMMP20 enamelysin

2jsd - hMMP catalytic domain + inhibitor - NMR

MMP23 CA-MMPMMP23 CA-MMP

2k72 – hMMP residues 254-290 - NMR