Calcium/Calmodulin-dependent protein kinase
Ca2+/Calmodulin dependent protein kinase (CaMK) phosphorylates Ser and Thr. It is regulated by Ca2+/Calmodulin (CaM). It contains an N-terminal catalytic domain, regulatory domain (CBD) and association domain (ASD). CaMKI is a specialized CaM kinase while CaMKII is multifunctional kinase. CASK is a membrane associated CaMK. DAPK is a death-associated CaMK which protects cells from some programmed cell death. It contains a regulatory (RD) and autoinhibitory (AD) domains. The images at the left and at the right correspond to one representative CaMK, i.e. crystal structure of human native membrane associated Ca2+/Calmodulin dependent protein kinase (3mfr).
3D Structures of Ca2+/Calmodulin dependent protein kinase3D Structures of Ca2+/Calmodulin dependent protein kinase
CaMKI – specialized CaM kinaseCaMKI – specialized CaM kinase
3nyv – TgCaMK+WHI-P180 – Toxoplasma gondii
3n51 - TgCaMK CBD +RM-1-95
3i7b - TgCaMK CBD+ NM-PP1
3i7c - TgCaMK CBD+ NA-PP2
3ku2 - TgCaMK CBD
3khe, 3i79, 3hzt – TgCaMK
3hx4 – TgCaMK+Ca
3dxn – TgCaMK kinase domain
3mwu – CpCaMK CBD (mutant)+RM-1-95 – Cryptosporidium parvum
3ncg - CpCaMK CBD + NM-PP1
3lij – CpCaMK+Ca
3l19, 3igo, 3hko – CpCaMK
2qg5 – CpCaMK chains A, B, D
3f3z – CpCaMK kinase domain+indirubin_E804
3dfa - CpCaMK kinase domain
2aao – CaMK chains A, B – Arabidopsis thaliana
1iq5 – CeCaMK CBD+XlCaM – Xenopus laevis
1s6j – sCaMK α chain A N-terminal – soybean
1s6i - sCaMK α chain A C-terminal+CaM-like domain
1mxe – rCaMKI CBD+CaM – rat
1ckk – rCaMK CBD chain B+XlCaM
1a06 – rCaMK chain A
CASK – membrane-associated CaMKCASK – membrane-associated CaMK
3mfr – hCASK CBD – human
3mfs – hCASK+AMPPNP
3mft – hCASK+Mn
3c0g – hCASK kinase domain
3c0h - hCASK kinase domain+AMPPNP
3c0i - hCASK kinase domain+AMP
3mfu - hCASK+AMPPNP+Mn
DAPK – death-associated CaMKDAPK – death-associated CaMK
2x0g – hDAPK RD+AD+CaM
2cke – hDAPK+inhibitor
CaMKII – multifunctional CaM kinaseCaMKII – multifunctional CaM kinase
2vz6 - hCaMKII α chains A, B+ indirubin-E804
2zv2 – hCaMKII+STO-609
2wel - hCaMKII δ chain D+CaM
2w2c - hCaMKII δ chain ASD
2vn9 - hCaMKII δ chains A-B
3bhh - hCaMKII β chains A-D
2v7o - hCaMKII γ chain A
2ux0 - hCaMKII γ (mutant) chains A-F
2jam - hCaMKI γ+peptides
2jc6 - hCaMKII δ chains A,C
1hkx - mCaMKII α chains A-N ASD - mouse
3gp2 – cCaMKII δ chain B+CaM – chicken
3kk8, 3kk9 – CeCaMKII – Caenorhabditis elegans
3kl8 – CeCaMKII (mutant)+inhibitor
3ksp – CaMKII ASD – Exiguobacterium sibiricum
CaMKIVCaMKIV
2w4o – hCaMKIV+inhibitor