Villin

File:2k6n.png

Crystal Strcture of the Human Supervillin Headpiece, 2k6n

Template:STRUCTURE 2k6n Villin (VIL) is an actin-binding protein. The images on the left and right correspond to one representative villin structure, i.e. the human supervillin headpiece (2k6n). It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons.

3D Structures of Villin3D Structures of Villin

SupervillinSupervillin

2k6m, 2k6n – hSVIL headpiece– human – NMR

VillinVillin

3fg7 – hVIL gelsolin domains 4-6
1unc – hVIL headpiece
3iur - hVIL headpiece H2H3 helices+prolyl endopeptidase – Aeromonas punctata
2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8 – cVIL headpiece (mutant) – chicken
1yu5, 1qqv - cVIL headpiece
1vii, 2vik, 2vil - cVIL headpiece - NMR
2ppz, 2jm0 - VIL headpiece (mutant) – synthetic – NMR
2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL fragment (mutant) – synthetic

AdvillinAdvillin

1und – hAVIL headpiece