Porin

Porin or Outer Membrane Proteins (Omps) act as channels which allow passive diffusion of sugars, ions and amino acids. They are beta barrel proteins which traverse the cell membrane. In E. coli they are named according to their genes: C, F, G (OmpC, OmpF, Ompg). Voltage-Dependent Anion Channel (VDAC) is ion channel Omp found in outer mitochondrial membrane. In Pseudomonas aeruginosa the porin gene products are named OprD, OprK, OprP. The images at the left and at the right correspond to one representative porin structure, i.e. crystal structure osmoporin OmpC from Escherichia coli (2j1n). OmpC has three beta-barrels associated to form a ^[1].

File:Ompc.png

Crystal structure of Porin OmpC from E. coli, 2j1n

Porin OmpC from E. coli, 2j1n

Ligands:

, ,

Structural annotation:
Resources:	CATH : 2J1Na00, 2J1Nb00, 2J1Nc00 InterPro : Ipr023614, Ipr001702, Ipr001897, Ipr013793 Pfam : PF00267

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

PorinPorin

2xe5, 2xe1, 2xe2, 2xe3, 2j1n – EcOmpC – Escherichia coli
2j4u – EcOmpC+lactotransferrin fragment
3k19, 3k1b, 2zfg, 1omf, 2omf, 1opf – EcOmpF
1hxt, 1hxu, 1hxx, 1bt9, 1gfm, 1gfn, 1gfo, 1gfp, 1gfq, 1mpf – EcOmpF (mutant)
2zld – EcOmpF+colicin E3
3o0e - EcOmpF+colicin peptide
3hw9, 3hwb – EcOmpF+ions
3fyx – EcOmpF+dibenzo-18-crown-6
2iwv, 2iww, 2f1c - EcOmpG
2wjq, 2wjr – EcOmp NANC
1af6, 1mpq, 1mpm, 1mpn, 1mpo – EcOmp LAMB+sugars
1pho - EcOmp
3a2r – NmOmpB – Neisseria meningitides
3a2s, 3a2t – NmOmpB+sugars
3a2u - NmOmpB+AMPPNP
3jty – Omp – Pseudomonas fluorescens
2qtk – PaOprK – Pseudomonas aeruginosa
2odj - PaOprD
2o4v – PaOprP+phosphate
2v9u – MsOmp rim domain – Mycobacteria smegmatis
1uun – MsOmp (mutant)
2fgq – DaOmp32+malate – Delftia acidovorans
2fgr - DaOmp32
1e54 – Omp32+sulfate – Comamonas acidovorans
1oh2, 1a0t – StOmp+sucrose – Salmonella typhimurium
1a0s, 1mpr - StOmp
1h6s – RbOmp+inserted sequence – Rhodopseudomonas blastica
2prn, 1bh3, 3prn, 5prn, 6prn, 7prn, 8prn – RbOmp (mutant)
1prn - RbOmp
1osm – OmpK36 – Klebsiella pneumoniae
2por, 3por – Omp – Rhodobacter capsulatus

Voltage-Dependent Anion ChannelVoltage-Dependent Anion Channel

2jk4 – hVDAC-1 – human
2k4t - hVDAC-1 - NMR
3emn – VDAC-1 - mouse

ReferencesReferences

↑ Basle A, Rummel G, Storici P, Rosenbusch JP, Schirmer T. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. J Mol Biol. 2006 Oct 6;362(5):933-42. Epub 2006 Aug 3. PMID:16949612 doi:10.1016/j.jmb.2006.08.002

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman, Karsten Theis

[1] Basle A, Rummel G, Storici P, Rosenbusch JP, Schirmer T. Crystal structure of osmoporin OmpC from E. coli at 2.0 A. J Mol Biol. 2006 Oct 6;362(5):933-42. Epub 2006 Aug 3. PMID:16949612 doi:10.1016/j.jmb.2006.08.002

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