Annexin

File:1ain.png

Crystal Structure of Human Annexin I, 1ain

3D Structure of Annexin

Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein.

Annexin IAnnexin I

2q4c, 1ycn - AnI - Arabidopsis thaliana
1mcx, 1hm6 - pAnI - pig
1qls - pAnI head+calgizzarrin
1bo9 - hAnI head - human NMR
1ain - hAnI

Annexin IIAnnexin II

2hyu, 2hyv - hAnII+heparin oligosaccharide
2hyw, 1xjl - hAnII+Ca
1w7b - hAnII
1bt6 - hAnII head+calpactin light chain

Annexin IIIAnnexin III

1aii, 1axn - hAnIII

Annexin IVAnnexin IV

2zhi, 2zhj, rAnIV+Na - rat
2zoc - hAnIV
1i4a - cAnIV (mutant) - cow
1aow, 1ann - cAnIV

Annexin VAnnexin V

2ie6, 2ie7, rAnV
1n41, 1n42, 1n44, 2h0k, 2h0l, 2h0m, 1bc0, 1bc1, 1bc3, 1bcw, 1bcy, 1bcz - rAnV (mutant)
1g5n - rAnV+ heparin oligosaccharide
1a8a, 1a8b - rAnV+phospholipid analog
2ran - rAnV+Ca
2yii - chAnV+Ca - chicken
1yj0 - chAnV+Zn
1ala - ChAnV
1hak - hAnV+K-201
1sav - hAnV (thioproline)
1hvd, 1hve, 1hvf, 1hvg - hAnV (mutant)
1anw, 1avh, 1avr - hAnV
1anx - hAnV+Ca

Annexin VIAnnexin VI

1m9i - hAnVI (mutant)
1avc - cAnVI+Ca

Annexin VIIIAnnexin VIII

1w3w - hAnVIII
1w45 - hAnVIII (mutant)

Annexin XIIAnnexin XII

1dm5 - HvAnXII (mutant) - Hydra vulgaris
1aei - HvAnXII

Other annexinsOther annexins

1dk5 - An24 - Capsicom annuum
3brx - coAnGH1+Ca - cotton
1n00 - coAnGH1