Crystal Structure of calcium-bound cotton annexin Gh1Crystal Structure of calcium-bound cotton annexin Gh1
Structural highlights
3brx is a 1 chain structure with sequence from Gossypium hirsutum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
ANX1_GOSHI Binds to phospholipid vesicles in a calcium-dependent manner in vitro (PubMed:16331990, PubMed:18441010). Prefers phosphatidyl-serine containing membranes. May have a role in the membrane cytoskeleton scaffolding or exocytotic processes (PubMed:16331990). May be involved in oxidative stress response (Probable).[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Dabitz N, Hu NJ, Yusof AM, Tranter N, Winter A, Daley M, Zschornig O, Brisson A, Hofmann A. Structural determinants for plant annexin-membrane interactions. Biochemistry. 2005 Dec 13;44(49):16292-300. doi: 10.1021/bi0516226. PMID:16331990 doi:http://dx.doi.org/10.1021/bi0516226
↑Hu NJ, Yusof AM, Winter A, Osman A, Reeve AK, Hofmann A. The crystal structure of calcium-bound annexin Gh1 from Gossypium hirsutum and its implications for membrane binding mechanisms of plant annexins. J Biol Chem. 2008 Jun 27;283(26):18314-22. Epub 2008 Apr 25. PMID:18441010 doi:10.1074/jbc.M801051200
↑Hofmann A, Delmer DP, Wlodawer A. The crystal structure of annexin Gh1 from Gossypium hirsutum reveals an unusual S3 cluster. Eur J Biochem. 2003 Jun;270(12):2557-64. PMID:12787021
