Fibrinogen

Fibrinogen is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, thrombin, exposing Knobs A & B to form fibrin. It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained.

File:3hus2.jpg

Crystal Structure of Fibrinogen with peptide ligand, 3hus

Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, 3hus

Drag the structure with the mouse to rotate

3D Structure of Fibrinogen3D Structure of Fibrinogen

Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) .

Fibrinogen alpha+beta+gamma chainsFibrinogen alpha+beta+gamma chains

3hus, 3h32, 3e1i, 3bvh, 2hlo, 2hod, 2hpc, 2oyh, 2oyi, 2h43, 2ffd, 1re3, 1rf1, 1n86, 1ltj – hFba+hFbb+hFbg+peptide ligand – human
3ghg, 2q9i, 2z4e - hFba+hFbb+hFbg+knob A & B
2a45 - hFba+hFbb+hFbg+thrombin+PPACK thrombin inhibitor
1re4, 1rf0, 1n8e, 1lt9 - hFba+hFbb+hFbg
1jy3, 1deq – cFba+cFbb+cFbg - cow
1n73, 1lwu - Fba+Fbb+Fbg+peptide ligand – Sea lamprey
1m1j - heFba+heFbb+heFbg+peptide ligand – hen
1ei3 - heFba+heFbb+heFbg

Fibrinogen alpha chainFibrinogen alpha chain

1fzd – hFba EC domain
2jor – cFba – NMR
2baf – cFba

Fibrinogen beta chainFibrinogen beta chain

1fzf, 1fzg – hFb fragment double-D +peptide ligand
1fze, 1fza, 1fzb – hFb fragment D

Fibrinogen gamma chainFibrinogen gamma chain

2vr3 – hFbg+SaClumping Factor A – Staphylococcus aureus
2vdo, 2vdp, 2vdq, 2vdr – hFbg+Integrin alpha IIB+Integrin beta-3+Monoclonal antibody heavy and light chains
2fib, 3fib - hFbg+peptide ligand
1fib – hFbg+Ca
1fic, 1fid - hFbg

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

David Canner, Angel Herraez, Alexander Berchansky, Michal Harel, Mark Hoelzer