Inosine monophosphate dehydrogenase

Function Inosine monophosphate dehydrogenase (IMPDH) is part of the GTP biosynthesis and catalyzes the conversion of inosine monophosphate to xanthosine monophosphate while reducing NAD. IMPDH is inhibited by ribavirin and mycophenolic acid.

spinqualitylabelsall models Structure of IMPDH complex with inosinic acid, K+ (purple) and the inhibitor mycophenolic acid (PDB code 4fo4). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of inosine monophosphate dehydrogenase3D structures of inosine monophosphate dehydrogenase

Updated on 26-April-2015

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• IMPDH
  • 1ak5 – TfIMPDH – Tritrichomonas foetus
    
  • 1eep – IMPDH – Borellia burgdorferi
    
  • 1zfj – IMPDH catalytic domain – Streptococcus pyogenes
    
  • 1vrd – IMPDH – Thermotoga maritima
    
  • 3ffs – CpIMPDH – Cryptosporidium parvum
    
  • 3r2g – IMPDH – Legionella pneumophila
    
  • 3tsb, 4mjm, 4myx – BaIMPDH (mutant) – Bacillus anthracis
    
  • 4fez – VcIMPDH – Vibrio cholerae
    
  • 4avf, 3zfh – PaIMPDH – Pseudomonas aeruginosa
    
• IMPDH binary complex
  • 1me8 – TfIMPDH + ribavirin monophosphate
    
  • 1pvn – TfIMPDH catalytic domain + transition state analog
    
  • 1me9 – TfIMPDH + inosinic acid
    
  • 2cu0 – IMPDH + xanthosine monophosphate – Pyrococcus horikoshii
    
  • 3tsd – BaIMPDH (mutant) + xanthosine monophosphate
    
  • 3usb – BaIMPDH + inosinic acid
    
  • 4ix2 – VcIMPDH + inosinic acid
    
  • 4qq3 – VcIMPDH (mutant) + XMP
    
  • 4dqw – PaIMPDH + ATP
    
  • 1jcn – hMPDH 1 + IMP derivative - human
    
  • 1jr1 – hMPDH 2 + mycophenolic acid
    
  • 4r7j – CjIMPDH catalytic domain (mutant) + inosinic acid – Campylobacter jejuni
    
• IMPDH ternary complex
  • 1me7 – TfIMPDH + ribavirin monophosphate + mycophenolic acid
    
  • 1lrt – TfIMPDH + adenine derivative + inosinic acid
    
  • 1meh – TfIMPDH + mycophenolic acid + inosinic acid
    
  • 1mei – TfIMPDH + mycophenolic acid + xanthosine monophosphate
    
  • 1mew – TfIMPDH + NAD + xanthosine monophosphate
    
  • 4fo4, 4fxs – VcIMPDH + mycophenolic acid + inosinic acid
    
  • 4hlv – VcIMPDH + NAD + inosinic acid
    
  • 4qne – VcIMPDH (mutant) + NAD + IMP
    
  • 4x3z – VcIMPDH (mutant) + NAD + XMP
    
  • 4ixh, 3khj, 4qj1 – CpIMPDH catalytic domain + inhibitor + inosinic acid
    
  • 4rv8 - CpIMPDH catalytic domain (mutant) + inhibitor + inosinic acid
    
  • 4my1, 4mya, 4mxs, 4my9, 4qm1 – BaIMPDH catalytic domain (mutant) + inhibitor + inosinic acid
    
  • 4mz1, 4mz8 – CjIMPDH catalytic domain (mutant) + inhibitor + inosinic acid
    
  • 4q32, 4q33 – MPDH + IMP + inhibitor – Clostridium perfringens
    
  • 4af0 – IMPDH + mycophenolic acid + inosinic acid – Cryptococcus neoformans
    
  • 1b3o – hMPDH 2 + selenazole inhibitor + IMP derivative
    
  • 1nfb – hMPDH 2 + NAD + IMP derivative
    
  • 1nf7 – hMPDH 2 + mycophenolic adenine dinucleotide + ribavirin monophosphate