2c0z

The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroidesThe 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides

Structural highlights

2c0z is a 1 chain structure with sequence from Streptomyces niveus NCIMB 11891. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.6Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOVW_STRNV dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase that acts together with NovU to catalyze the formation of dTDP-4-keto-6-deoxy-5-C-methyl-L-lyxo-hexose from dTDP-4-keto-6-deoxy-D-glucose in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Thuy TT, Lee HC, Kim CG, Heide L, Sohng JK. Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides. Arch Biochem Biophys. 2005 Apr 1;436(1):161-7. PMID:15752721 doi:10.1016/j.abb.2005.01.012
↑ Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chem Commun (Camb). 2006 Mar 14;(10):1079-81. PMID:16514445 doi:10.1039/b515763c

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OCA

[1] Thuy TT, Lee HC, Kim CG, Heide L, Sohng JK. Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides. Arch Biochem Biophys. 2005 Apr 1;436(1):161-7. PMID:15752721 doi:10.1016/j.abb.2005.01.012

[2] Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chem Commun (Camb). 2006 Mar 14;(10):1079-81. PMID:16514445 doi:10.1039/b515763c

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2c0z

Structural highlights

Function

Evolutionary Conservation

References

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2c0z

Structural highlights

Function

Evolutionary Conservation

References

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