The 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroidesThe 1.6 A resolution crystal structure of NovW: a 4-keto-6-deoxy sugar epimerase from the novobiocin biosynthetic gene cluster of Streptomyces spheroides
Structural highlights
2c0z is a 1 chain structure with sequence from Streptomyces niveus NCIMB 11891. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NOVW_STRNV dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase that acts together with NovU to catalyze the formation of dTDP-4-keto-6-deoxy-5-C-methyl-L-lyxo-hexose from dTDP-4-keto-6-deoxy-D-glucose in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Thuy TT, Lee HC, Kim CG, Heide L, Sohng JK. Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides. Arch Biochem Biophys. 2005 Apr 1;436(1):161-7. PMID:15752721 doi:10.1016/j.abb.2005.01.012
↑Tello M, Jakimowicz P, Errey JC, Freel Meyers CL, Walsh CT, Buttner MJ, Lawson DM, Field RA. Characterisation of Streptomyces spheroides NovW and revision of its functional assignment to a dTDP-6-deoxy-D-xylo-4-hexulose 3-epimerase. Chem Commun (Camb). 2006 Mar 14;(10):1079-81. PMID:16514445 doi:10.1039/b515763c
