1xbr

T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNAT DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA

Structural highlights

1xbr is a 4 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TBXT_XENLA Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation (PubMed:11869292). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (PubMed:11111039). Causes dorsal mesodermal differentiation of animal cap ectoderm when co-expressed with wnt8 and noggin (PubMed:7906224). None of these molecules causes dorsal mesoderm formation when expressed alone (PubMed:7906224). Establishes the left/right axis at early gastrula stage by directly up-regulating mesodermal expression of zic3 (PubMed:11869292).^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Sinha S, Abraham S, Gronostajski RM, Campbell CE. Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene. 2000 Nov 27;258(1-2):15-29. PMID:11111039 doi:10.1016/s0378-1119(00)00417-0
↑ Kitaguchi T, Mizugishi K, Hatayama M, Aruga J, Mikoshiba K. Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev Growth Differ. 2002 Feb;44(1):55-61. PMID:11869292
↑ Cunliffe V, Smith JC. Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8. EMBO J. 1994 Jan 15;13(2):349-59. PMID:7906224

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OCA

[1] Sinha S, Abraham S, Gronostajski RM, Campbell CE. Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene. 2000 Nov 27;258(1-2):15-29. PMID:11111039 doi:10.1016/s0378-1119(00)00417-0

[2] Kitaguchi T, Mizugishi K, Hatayama M, Aruga J, Mikoshiba K. Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev Growth Differ. 2002 Feb;44(1):55-61. PMID:11869292

[3] Cunliffe V, Smith JC. Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8. EMBO J. 1994 Jan 15;13(2):349-59. PMID:7906224

[1]

[2]

[3]

1xbr

T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNAT DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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1xbr

T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNAT DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA

Structural highlights

Function

Evolutionary Conservation

See Also

References

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