T DOMAIN FROM XENOPUS LAEVIS BOUND TO DNAT DOMAIN FROM XENOPUS LAEVIS BOUND TO DNA
Structural highlights
1xbr is a 4 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
TBXT_XENLA Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation (PubMed:11869292). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence (PubMed:11111039). Causes dorsal mesodermal differentiation of animal cap ectoderm when co-expressed with wnt8 and noggin (PubMed:7906224). None of these molecules causes dorsal mesoderm formation when expressed alone (PubMed:7906224). Establishes the left/right axis at early gastrula stage by directly up-regulating mesodermal expression of zic3 (PubMed:11869292).[1][2][3]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Sinha S, Abraham S, Gronostajski RM, Campbell CE. Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. Gene. 2000 Nov 27;258(1-2):15-29. PMID:11111039 doi:10.1016/s0378-1119(00)00417-0
↑Kitaguchi T, Mizugishi K, Hatayama M, Aruga J, Mikoshiba K. Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev Growth Differ. 2002 Feb;44(1):55-61. PMID:11869292
↑Cunliffe V, Smith JC. Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8. EMBO J. 1994 Jan 15;13(2):349-59. PMID:7906224
