1pft

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N-TERMINAL DOMAIN OF TFIIB, NMRN-TERMINAL DOMAIN OF TFIIB, NMR

Structural highlights

1pft is a 1 chain structure with sequence from Atcc 43587. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:PYROCOCCUS FURIOSUS TFIIB GENE (ATCC 43587)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TF2B_PYRFU] Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The three-dimensional structure of the N-terminal domain of an archaeal TFIIB, which has high sequence homology with eucaryal analogues, is strikingly similar to that of the C-terminal zinc ribbon of the eucaryal transcription elongation factor TFIIB.

The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon.,Zhu W, Zeng Q, Colangelo CM, Lewis M, Summers MF, Scott RA Nat Struct Biol. 1996 Feb;3(2):122-4. PMID:8564536[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Zhu W, Zeng Q, Colangelo CM, Lewis M, Summers MF, Scott RA. The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon. Nat Struct Biol. 1996 Feb;3(2):122-4. PMID:8564536
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