3v8d

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Crystal structure of human CYP7A1 in complex with 7-ketocholesterolCrystal structure of human CYP7A1 in complex with 7-ketocholesterol

Structural highlights

3v8d is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Gene:CYP7A1, CYP7 (HUMAN)
Activity:Cholesterol 7-alpha-monooxygenase, with EC number 1.14.13.17
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.[1]

References

  1. ↑ Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010 Apr;51(4):832-42. doi: 10.1194/jlr.M002782. Epub 2009 Oct 28. PMID:19965590 doi:http://dx.doi.org/10.1194/jlr.M002782

3v8d, resolution 1.90Å

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