3v8d

Crystal structure of human CYP7A1 in complex with 7-ketocholesterolCrystal structure of human CYP7A1 in complex with 7-ketocholesterol

Structural highlights

3v8d is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CP7A1_HUMAN Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.^[1]

References

↑ Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010 Apr;51(4):832-42. doi: 10.1194/jlr.M002782. Epub 2009 Oct 28. PMID:19965590 doi:http://dx.doi.org/10.1194/jlr.M002782

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OCA

[1] Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010 Apr;51(4):832-42. doi: 10.1194/jlr.M002782. Epub 2009 Oct 28. PMID:19965590 doi:http://dx.doi.org/10.1194/jlr.M002782

[1]

3v8d

Crystal structure of human CYP7A1 in complex with 7-ketocholesterolCrystal structure of human CYP7A1 in complex with 7-ketocholesterol

Structural highlights

Function

References

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3v8d

Crystal structure of human CYP7A1 in complex with 7-ketocholesterolCrystal structure of human CYP7A1 in complex with 7-ketocholesterol

Structural highlights

Function

References

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