Geranylgeranyl pyrophosphate synthase

File:2z4v.png

Crystal Structure of geranylgeranyl pyrophosphate synthase complex with GGPP and Mg+2 2z4v

Geranylgeranyl pyrophosphate synthase (GGPPS) catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP) from farnesyl diphosphate and isopentenyl diphosphate. GGPPS is involved in the addition of hydrophobic molecules to proteins and in the regulation of a nuclear hormone receptor.

3D Structures of geranylgeranyl pyrophosphate synthase3D Structures of geranylgeranyl pyrophosphate synthase

Updated on 10-April-2013

2dh4 – yGGPPS + Mg - yeast
2e8t – yGGPPS + Mg + isopentenyl pyrophosphate + farnesyl thiopyrophosphate
2e8u, 2e8w – yGGPPS + Mg + isopentenyl pyrophosphate
2e8v – yGGPPS + GGPP
2z4v – yGGPPS + GGPP + Mg
2e8x – yGGPPS + GPP + Mg
2e90 – yGGPPS + Mg + PP + farnesyl pyrophosphate
2e91, 2e92, 2e93, 2e94, 2e95, 2z7h, 2z4w, 2z4x, 2z4y, 2z4z, 2z50, 2z52, 2z78, 2z7i, 2zeu – yGGPPS + Mg + inhibitor
2zev – yGGPPS + Mg + isopentenyl pyrophosphate + inhibitor
2q80 – GGPPS + GGPP + Mg - human