Chaperonin 3D structures

3D Structures of Chaperonin3D Structures of Chaperonin

Updated on 26-January-2025

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• Group I

• Large subunit or Hsp60 Heat shock protein

• • 7v94 – GroEL (mutant) – grouper
  • 3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis
    
  • 1sjp, 3rtk – MtGroEL2 residues 42-539
    
  • 4v43, 2yey, 4wsc, 4wgl, 5opw – EcGroEL (mutant) - Escherichia coli
    
  • 1oel, 1xck, 1ss8, 2nwc, 4hel – EcGroEL
    
  • 1gr5, 2ynj, 3c9v, 3cau, 5w0s, 7xoj, 7xok, 7xol, 7xom, 7xon, 7xoo, 7xop, 7xoq, 7xor, 7xos, 9c0c – EcGroEL – Cryo EM
    
  • 2c7e, 4aaq - EcGroEL (mutant) – Cryo EM
    
  • 1fy9, 1fya, 1kid, 3vz6, 3vz7, 3vz8 – EcGroEL apical domain (mutant)
    
  • 3osx - Cpn60 apical domain – Xenorhabdus nematophila
    
  • 1iok – Cpn60 – Paracoccus denitrificans
    
  • 5da8 - GroEL – Chlorobium tepidum
    
  • 5cdk, 5cdj, 5cdi - GroEL apical domain – Chlamydomonas reinhardtii
    
  • 6kfv - GroEL – Xanthomonas oryzae
    
  • 8wu4 - HtGroEL – Hydrogenophilus thermoluteolus – Cryo EM
    
  • 9c0d - GroEL – Enterococcus faecium – Cryo EM
    

•Human mitochondrial chaperonin or Hsp60, Hsp10 see [[Heat Shock Proteins]

• Large subunit binary complex

• • 1sx3 - EcGroEL + ATP
  • 1kp8 - EcGroEL (mutant) + ATP
  • 8bl2, 8bl7, 8blc, 8bld, 8ble, 8blf, 8bly - EcGroEL + ATP – Cryo EM
  • 4aar, 4aas, 4aau, 4ab2, 4ab3, 8g7l - EcGroEL (mutant) + ATP – Cryo EM
  • 8p4p - EcGroEL + ATP + ADP – Cryo EM
  • 8ba7, 8ba8, 8ba9 - EcGroEL + ADP + RuBisco – Cryo EM
  • 9c0b - EcGroEL + inhibitor – Cryo EM
  • 1mnf – EcGroEL + peptide
  • 8s32 - EcGroEL + peptide – Cryo EM
  • 7ywy - EcGroEL + chaperedoxin – Cryo EM
  • 1sx4 - EcGroEL + ADP
  • 4ki8 - EcGroEL (mutant) + ADP
    
  • 7k3z – Cpn60 (mutant) + ATP – Plasmodium falciparum
    

• Small subunit

• • 3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
    
  • 1wnr – TtCpn10 residues 1-94
    
  • 1p3h, 1hx5 – MtCpn10
    
  • 1p82, 1p83 - MtCpn10 residues 1-25 - NMR
    
  • 1egs - GroES residues 19-27 - NMR

• Large + small subunit

• • 1svt, 1pcq - EcGroEL + GroES
    
  • 1pf9, 1aon, 4pko, 5opx - EcGroEL + GroES + ADP
    
  • 2c7d - EcGroEL + GroES + ADP – Cryo EM
  • 3zpz, 3zq0, 3zq1, 7pbj, 7pbx, 8p4m, 8p4n, 8qxs, 8qxt - EcGroEL + GroES + ADP – Cryo EM
    
  • 8bkz, 8bm0, 8bm1, 8bmd, 8bmo, 8bmt, 8p4r - EcGroEL + GroES + ATP – Cryo EM
    
  • 3wvl - EcGroEL (mutant) + GroES + ATP
    
  • 8g7n - EcGroEL (mutant) + GroES + ATP – Cryo EM
    
  • 8qxu, 8qxv - EcGroEL + GroES + ATP + ADP – Cryo E tomography
    
  • 3zpz, 3zq0, 3zq1, 7pbj, 7pbx - EcGroEL + GroES + ADP – Cryo EM
    
  • 7vwx - EcGroEL + GroES + RuBisCO – Cryo EM
    
  • 8p4o - EcGroEL + GroES + SAM synthase + ADP – Cryo EM
    
  • 4pkn - TtCpn60 + Cpn10 + ADP
  • 8wuc, 8wuw, 8wux - HtGroEL + GroES + ADP – Cryo EM
    

• Group II

• • 3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf, 3j3x, 7r9e, 7r9h, 7r9i, 7r9j, 7r9k, 7r9m, 7r9o, 7r9u – MmCpn – Methanococcus maripaludis – Cryo EM
    
  • 3kfb, 3kfe, 3kfk – MmCpn
    
  • 5w79 - MmCpn (mutant)
    
  • 3j02, 3j03 – MmCpn (mutant) – Cryo EM
    
  • 3ruq - MmCpn + ADP
    
  • 3rus, 5w74 - MmCpn (mutant) + ADP
    
  • 7rak – MmCpn + ATP – Cryo EM
    
  • 3ruw - MmCpn (mutant) + ADP-AlF3
    
  • 3ruv - MmCpn (mutant) + ATP analog
    

• CCT or TRiC

• • 7x7y - hCpn CCT – Cryo EM
    
  • 6krd, 6kre, 6ks6, 6ks8, 6qb8, 7wz3, 7x0a, 7x0v, 7x3u, 8hki - hCpn CCT + ADP – Cryo EM
    
  • 7lum, 7x6q - hCpn CCT + ATP – Cryo EM
    
  • 6nr8, 6nr9, 6nrb, 6nrc, 6nrd - hCpn CCT + HPFD – Cryo EM
    
  • 7lup - hCpn CCT + sigma 3 – Cryo EM
    
  • 7nvl, 7nvo - hCpn CCT + nanobody – Cryo EM
    
  • 7nvn, 7trg, 7tub, 7x3j - hCpn CCT + tubulin + ADP – Cryo EM
    
  • 7wu7 - hCpn CCT + prefoldin + ADP – Cryo EM
    
  • 8i1u, 8i9u - hCpn CCT G + phosducin-like protein + ADP – Cryo EM
    
  • 7nvm - hCpn CCT G + phosducin-like protein + actin + nanobody + ADP – Cryo EM
    
  • 8sfe, 8sff, 8sg8, 8sg9, 8sgc, 8sgl, 8sgq, 8sh9, 8sha, 8shd, 8she, 8shf, 8shg, 8shl, 8shn, 8sho, 8shp, 8shq, 8sht - hCpn CCT G + phosducin-like protein + guanine nucleotide-binding protein subunit beta-5 + ADP – Cryo EM
    
  • 2xsm, 4b2t – bCpn CCT – bovine
    
  • 3iyg, 4a0o - bCpn CCT – Cryo EM
    
  • 4a0v - bCpn CCT + AMPPNP – Cryo EM
    
  • 4a0w - bCpn CCT + ADP + AlF3 – Cryo EM
    
  • 4a13 - bCpn CCT + ADP – Cryo EM
    
  • 3ktt - bCpn CCT β subunit – Cryo EM
    
  • 1gml, 1gn1 - Cpn CCT γ subunit apical domain – mouse
    
  • 4v81, 4v94, 4v8r – Cpn CCT - yeast
    

• Hsp33 see Heat Shock Proteins

• chaperonin11 or Hsp10

• • 7ekq – Chap11 in ClpP complex – Chlamydomonas smithii – Cryo EM
    

• Thermosome

• • 1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
    
  • 1a6e - TaTherm α+β subunits + ADP
    
  • 1ass, 1asx - TaTherm α apical domain
    
  • 1e0r – TaTherm β apical domain
    
  • 3ko1 – AtTherm α subunit– Acidianus tengchongensis
    
  • 3j1b, 3j1c, 3j1e - AtTherm α subunit – Cryo EM
    
  • 3j1f - AtTherm β subunit + ATP – Cryo EM
    
  • 3aq1 – Therm – Methanococcoides burtonii
    
  • 1q2v, 1q3r – TkTherm α subunit (mutant) – Thermococcus KS-1
    
  • 1q3q - TkTherm α subunit (mutant) + AMP-PNP
    
  • 1q3s - TkTherm α subunit (mutant) + ADP
    
  • 4xcd - SsTherm β subunit + ADP – Sulfolobus solfataricus
    
  • 4xcg, 4xci - SsTherm α+β subunits + ADP
    
  • 6xhi - SasTherm subunit + ADP – Saccharolobus solfataricus
    
  • 6xhj - SasTherm subunit + ATP
    
  • 1lep – Cpn10 – Mycobacterium leprae

• Group III

• Thermosome

• • 5x9u - ChTherm α subunit + ADP – Carboxydothermus hydrogenoformans
    
  • 5x9v - ChTherm α subunit + ANP
    

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