Ferric hydroxamate uptake receptor

Function Ferric hydroxamate uptake receptor or ferrichrome-binding periplasmic protein proteins FhuA, FhuB, FhuC and FhuD are involved in the uptake of the hydroxamate ferrichrome siderophore for use as an iron source. FhuA is the E. coli outer membrane transporter of ferrichrome and is the receptor of some phages and colicin M. FhuD is the E. coli receptor of ferric hydroxamate. For more details see FhuD. FhuE is the E. coli receptor of ferric coprogen and ferric-rhodotorulic acid. FoxA is the Pseudomonas ferrioxamine receptor . For more details see FhuD. Disease Haemophilus parasuis uses Fhu to capture iron and is the cause of the Glasser disease in pigs. Structural highlights includes (in cyan) and contains Fe atom. The (Hydrophobic, Polar).

spinqualitylabelsall models E. coli FhuA complex with ferrichrome and Fe+3 ion (orange) (PDB code 1by5). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of Ferric hydroxamate uptake receptor3D structures of Ferric hydroxamate uptake receptor

Updated on 23-June-2024

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• FhuD
  • 3hxp – BsFhuD – Bacillus subtilis
    
  • 1esz – EcFhuD + coprogen – Escherichia coli
    
  • 1k2v – EcFhuD + desferal
    
  • 1k7s – EcFhuD + albomycin-δ 2
    
  • 1efd – EcFhuD + gallichrome
• FhuD2
  • 4fna – SaFhuD2 – Staphylococcus aureus
    
  • 4fil – SaFhuD2 (mutant) + ferrioxamine + Zn
    
• FhuA
  • 1by3 – EcFhuA
    
  • 1qjq – EcFhuA (mutant) + Ni
    
  • 2fcp – EcFhuA + Ni
    
  • 1qkc – EcFhuA (mutant) + albomycin-δ 2 + Ni
    
  • 1fcp – EcFhuA + ferricrocin-iron + Ni
    
  • 1by5 – EcFhuA + ferrichrome + Fe
    
  • 1qfg – EcFhuA (mutant) + lipopolysaccharide + Ni
    
  • 1qff – EcFhuA (mutant) + lipopolysaccharide + ferricrocin-iron + Ni
    
  • 1fi1 – EcFhuA (mutant) + lipopolysaccharide + rifamycin + Ni
    
  • 2grx – EcFhuA (mutant) + TonB + ferricrocin-iron
    
  • 4cu4 – EcFhuA + lasso peptide
    
• FhuE
  • 6e4v – EcFhuE + coprogen
    
• FoxA
  • 6i98 – PaFoxA – Pseudomonas aeruginosa
    
  • 6i96 – PaFoxA + ferrioxamine