1kbh

Mutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTRMutual Synergistic Folding in the Interaction Between Nuclear Receptor Coactivators CBP and ACTR

Structural highlights 1kbh is a 2 chain structure with sequence from Homo sapiens and Mus musculus. The February 2010 RCSB PDB Molecule of the Month feature on Enhanceosome by David Goodsell is 10.2210/rcsb_pdb/mom_2010_2. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NCOA3_HUMAN Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also CREB-binding protein 3D structures Nuclear receptor coactivator

spinqualitylabelsall models 1kbh Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image