Nuclear receptor coactivator

Nuclear receptor coactivator (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors^[1].

NCOA1 shows histone acetyltransferase activity and is required for steroid hormone response.
NCOA2 is a DNA transcription coactivator with glucocorticoid receptor.
NCOA3 shows histone acetyltransferase activity.
NCOA5 is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.
NCOA7 may be a driver for beast cancer metastasis^[2]

Structural highlights

.
.
. Water molecules are shown as red spheres.
.
.

Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, 1oj5

Drag the structure with the mouse to rotate

3D structures of nuclear receptor coactivator3D structures of nuclear receptor coactivator

Updated on 17-July-2024

2c52 – hNCOA1 residues 920-970 + CREB-binding protein – human
1kbh, 6es7, 6sqc – hNCOA3 1040-1086 + CREB-binding protein – NMR
1v95 – hNCOA5 anticodon binding domain 197-313 – human – NMR
8arp – hNCOA7 781-942
1oj5 – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse
5y7w - mNCOA1A Pas-B domain + YL-2 peptide

ReferencesReferences

↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
↑ Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Oncol Lett. 2024 Apr 23;27(6):278. PMID:38699661 doi:10.3892/ol.2024.14411

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485

[2] Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Oncol Lett. 2024 Apr 23;27(6):278. PMID:38699661 doi:10.3892/ol.2024.14411

[1]

[2]