Luciferase

Function

Luciferase (Luc) or luciferin monooxygenase (Lucmo)is an oxidative enzyme used in bioluminescence. It catalyzes the oxidation of the pigment luciferin producing oxyluciferin and light^[1]. See detailed analysis in

See Colored & Bioluminescent Protein.

Relevance

Luc is used in biological research to assess gene transfection into cells where the Luc gene is added to the transfected gene and the light emission by Luc measured for indication of the transfection success^[2].

3D Structures of Luciferase

Luciferase 3D structures

Additional informationAdditional information

(2d1s)

Several organisms are bioluminescent, meaning that they produce light. Luciferase is one of the enzymes that catalyzes light emitting reactions in organisms.

For additional information, see: Colored & Bioluminescent Proteins

ReferencesReferences

↑ Meighen EA. Molecular biology of bacterial bioluminescence. Microbiol Rev. 1991 Mar;55(1):123-42. PMID:2030669
↑ Gould SJ, Subramani S. Firefly luciferase as a tool in molecular and cell biology. Anal Biochem. 1988 Nov 15;175(1):5-13. PMID:3072883

Additional LiteratureAdditional Literature

^{[xtra 1]}^{[xtra 2]}

↑ Marques SM, Esteves da Silva JC. Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions. IUBMB Life. 2009 Jan;61(1):6-17. PMID:18949818 doi:10.1002/iub.134
↑ Inouye S. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Cell Mol Life Sci. 2010 Feb;67(3):387-404. Epub 2009 Oct 27. PMID:19859663 doi:10.1007/s00018-009-0170-8

External ResourcesExternal Resources

Yahoo news coverage of luciferase studies funded research for military applications
Luciferase at Wikipedia
Luciferase: June 2006 Molecule of the Month as part of the series of tutorials that are at the RCSB Protein Data Bank and written by David S. Goodsell

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[1] Meighen EA. Molecular biology of bacterial bioluminescence. Microbiol Rev. 1991 Mar;55(1):123-42. PMID:2030669

[2] Gould SJ, Subramani S. Firefly luciferase as a tool in molecular and cell biology. Anal Biochem. 1988 Nov 15;175(1):5-13. PMID:3072883

[3] Marques SM, Esteves da Silva JC. Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions. IUBMB Life. 2009 Jan;61(1):6-17. PMID:18949818 doi:10.1002/iub.134

[4] Inouye S. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Cell Mol Life Sci. 2010 Feb;67(3):387-404. Epub 2009 Oct 27. PMID:19859663 doi:10.1007/s00018-009-0170-8

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Luciferase

Function

Relevance

3D Structures of Luciferase

Contents

Additional informationAdditional information

ReferencesReferences

Additional LiteratureAdditional Literature

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Luciferase

Function

Relevance

3D Structures of Luciferase

Additional informationAdditional information

ReferencesReferences

Additional LiteratureAdditional Literature

External ResourcesExternal Resources

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