2kro

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RDC refined high resolution structure of the third SH3 domain of CD2APRDC refined high resolution structure of the third SH3 domain of CD2AP

Structural highlights

2kro is a 1 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:Cd2ap, Mets1 (LK3 transgenic mice)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum

Function

[CD2AP_MOUSE] Required for cytokinesis (By similarity). Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.[1]

See Also

References

  1. ↑ Shih NY, Li J, Karpitskii V, Nguyen A, Dustin ML, Kanagawa O, Miner JH, Shaw AS. Congenital nephrotic syndrome in mice lacking CD2-associated protein. Science. 1999 Oct 8;286(5438):312-5. PMID:10514378
Drag the structure with the mouse to rotate

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OCA
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