CD2-associated protein

Function

CD2-associated protein (CD2AP) called also CMS, is a scaffolding protein which regulates actin cytoskeleton. CD2AP SH3 domain interacts with actin and a variety of membrane proteins. CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.^[1]^[2]

Disease

Haploinsufficiency of CD2AP is associated with susceptibility of glomerular disease

3D structures of CD2-associated protein

CD2-associated protein 3D structures

Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (magenta) (PDB entry 2j6o)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett. 2002 Oct 2;529(1):110-5. PMID:12354621
↑ Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880 doi:10.1074/jbc.M606411200

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Michal Harel, Alexander Berchansky

[1] Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett. 2002 Oct 2;529(1):110-5. PMID:12354621

[2] Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880 doi:10.1074/jbc.M606411200

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CD2-associated protein

Contents

Function

Disease

3D structures of CD2-associated protein

ReferencesReferences

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CD2-associated protein

Function

Disease

3D structures of CD2-associated protein

ReferencesReferences

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