Proteopedia

6cxm

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Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218Crystal structure of a dihydrofolate reductase from Mycobacterium smegmatis in complex with NADP and P218

Structural highlights

6cxm is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Dihydrofolate reductase, with EC number 1.5.1.3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[I7FC10_MYCS2] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.[PIRNR:PIRNR000194]

6cxm, resolution 2.65Å

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OCA
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