Atlastin

Function

Atlastin (ATN) is a GTPase and a Golgi body transmembrane protein. ATN was shown to be required in membrane fusion and ER formation in Drosophila melanogaster.^[1]

Disease

Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D.

Structural highlights

from human atlastin (PDB code 4ido).^[1]

Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code 4ido).

Drag the structure with the mouse to rotate

3D structures of atlastin3D structures of atlastin

Updated on 10-December-2015

3q5d, 3q5e, 3qnu, 3qof – hATN cytoplasmic domain + GDP – human
4idn – hATN cytoplasmic domain + GNP
4idp – hATN cytoplasmic domain (mutant) + GNP
4ido – hATN cytoplasmic domain + GDP + AlF4
4idq – hATN cytoplasmic domain (mutant) + GDP + AlF4

ReferencesReferences

↑ ^1.0 ^1.1 Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[Ad-1] 1.0 ^1.1 Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353

[1]