Function

Atlastin (ATN) is a GTPase and a Golgi body transmembrane protein. ATN was shown to be required in membrane fusion and ER formation in Drosophila melanogaster.[1]

Disease

Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. Mutations in ATL-3 affect multiple ER-related pathways[2].

Structural highlights

  • from human atlastin (PDB code 4ido).[1] Water molecules shown as red spheres.

3D structures of atlastin

Atlastin 3D structures


Structure of human atlastin cytoplasmic domain complex with GDP and AlF4 (PDB code 4ido).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. 1.0 1.1 Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353
  2. Behrendt L, Kurth I, Kaether C. A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways. Cell Mol Life Sci. 2019 Apr;76(7):1433-1445. doi: 10.1007/s00018-019-03010-x., Epub 2019 Jan 21. PMID:30666337 doi:http://dx.doi.org/10.1007/s00018-019-03010-x

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