Tumor necrosis factor receptor

Function Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. TNFRSF 1 is called Lymphotoxin-α or TNF-β; TNFRSF 3 is called TNFR-III; TNFRSF 4 is called OX40L receptor; TNFRSF 5 is called CD40L receptor; TNFRSF 6 is called Fas; TNFRSF 9 is called 4-1BBL; TNFRSF 10B is called Dr5; TNFRSF 11 is called RANKL; TNFRSF 11A is called RANK; TNFRSF 11B is called Osteoprotegerin; TNFRSF 12 is called TWEAK; TNFRSF 12A is called TWEAKR; TNFRSF 13 is called APRIL; TNFRSF 13B is called BAFF or sTALL-1; TNFRSF 13C is called BAFF receptor; TNFRSF 14 is called LIGHT; TNFRSF 16 is called Nerve growth factor receptor; TNFRSF 18 is called GITRL; TNFRSF 21 is called Dr6; Relevance TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR. Structural highlights The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues. The CRDs are involved in binding of TNF.

spinqualitylabelsall models Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code 1ext). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of tumor necrosis factor receptor3D structures of tumor necrosis factor receptor

Updated on 28-September-2016

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• Tumor necrosis factor receptor 1
  • 1ncf – hTNFR-1 residues 12-172 (mutant) – human
    
  • 1ich – hTNFR-1 death domain (mutant) - NMR
    
  • 2eqp – hTNFR-1 residues 28-70 – NMR
    
  • 1ext – hTNFR-1 extracellular domain
    
  • 1ft4 – hTNFR-1 extracellular domain + inhibitor
    
  • 3on9 – evTNFR SECRET domain – ectromelia virus
    
  • 3ona – evTNFR SECRET domain + CX3CL1
    
• Tumor necrosis factor receptor superfamily 1 (lymphotoxin-α, TNF-β)
  • 1tnr – hTNFRSF-1 + TNFβ
    
  • 4mxv – hTNFSF-1 extracellular domain + antibody - human
    
  • 4mxw – hTNFSF-1 extracellular domain + antibody + TNFR-III
    
• Tumor necrosis factor receptor superfamily 1B
  • 3alq – hTNFRSF-1B extracellular domain + TNF
    
• Tumor necrosis factor receptor superfamily-4 (OX40L receptor)
  • 2hew – mTNFSF-4 extracellular domain - mouse
    
  • 2hev – hTNFSF-4 extracellular domain + OX40 ligand
    
  • 2hey – mTNFSF-4 extracellular domain + hOX40 ligand
    
• Tumor necrosis factor receptor superfamily-5 (CD40L receptor)
  • 1aly – hTNFSF-5 extracellular domain
    
  • 1i9r, 5dmi, 5dmj, 5ihl – hTNFSF-5 extracellular domain + antibody
    
  • 3lkj – hTNFSF-5 extracellular domain + inhibitor
    
  • 3qd6 – hTNFRSF-5 extracellular domain + CD40 ligand
    
• Tumor necrosis factor receptor superfamily-6 (Fas)
  • 3thm, 3tje – hTNFRSF-6 extracellular domain + antibody
    
  • 3ezq – hTNFRSF-6 Fas DD domain + FADD
    
  • 3oq9 – mTNFRSF-6 Fas DD domain + FADD - mouse
    
• Tumor necrosis factor receptor superfamily-6B
  • 3mhd – hTNFRSF-6B extracellular domain
    
  • 4msv – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain
    
  • 4kgg, 4kgq, 4j6g – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain
    
  • 3mi8, 3k51 – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain
    
  • 5l36 – hTNFRSF-6B extracellular domain + hTNF ligand SF-6 extracellular domain
    
• Tumor necrosis factor receptor superfamily-9 (4-1BBL)
  • 2x29 – hTNFSF-9 extracellular domain (mutant)
    
• Tumor necrosis factor receptor superfamily-10B (Dr5)
  • 2h9g, 4od2, 1za3, 3x3f – hTNFRSF-10B extracellular domain + antibody
    
  • 1d0g – hTNFRSF-10B extracellular domain + apoptosis-2 ligand
    
  • 1d4v – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand
    
  • 4i9x – hTNFRSF-10B extracellular domain + UL141
    
  • 4n90 – hTNFRSF-10B + hTNFRSF-10 + antibody
    
• Tumor necrosis factor receptor superfamily-11 (RANKL)
  • 1jtz, 1iqa, 1s55 – mTNFSF-11 receptor-binding domain
    
  • 3me2, 3qbq, 4giq – mTNFSF-11 receptor-binding domain + RANK
    
  • 4e4d – mTNFSF-11 receptor-binding domain + osteoprotegerin
    
  • 3urf – hTNFSF-11 receptor-binding domain + osteoprotegerin
    
• Tumor necrosis factor receptor superfamily-11A (RANK)
  • 3me4 – mTNFRSF-11A extracellular domain
    
  • 5bnq – mTNFRSF-11A extracellular domain + TNF ligand SF-11
    
• Tumor necrosis factor receptor superfamily-11B (Osteoprotegerin)
  • 3urf – hTNFRSF-11B extracellular domain + TNFRSF-11B ligand
    
  • 4e4d – mTNFRSF-11B extracellular domain + TNFRSF-11B ligand
    
• TNFSF-12 superfamily member 12 (TWEAK)
  • 4ht1 – hTNFSF-12 extracellular domain + antibody
    
• Tumor necrosis factor receptor superfamily-12A (TWEAKR)
  • 2rpj, 2kmz, 2epq – hTNFRSF-12A cysteine-rich domain – NMR
    
• TNFSF-13 superfamily member 13 (APRIL)
  • 1u5x, 1u5y, 1u5z – mTNFSF-13 extracellular domain
    
  • 1xu1 – mTNFSF-13 extracellular domain + TNFSF-13B
    
  • 1xu2 – mTNFSF-13 extracellular domain + BCMA
    
  • 3k48 – mTNFSF-13 extracellular domain + peptide
    
  • 4zch – hTNFSF-13 extracellular domain + TNFSF-13B
    
• TNFSF-13B superfamily member 13B (BAFF, sTALL-1)
  • 1jh5, 1kxg, 1kd7, 4zch – hTNFSF-13B extracellular domain
    
  • 1oqd – hTNFSF-13B extracellular domain + B-cell maturation protein
    
  • 1oqe – hTNFSF-13B extracellular domain + hTNFRSF-13C
    
  • 4v46 – hTNFSF-13B extracellular domain + hTNFRSF-13C + BAFF
    
  • 1osg, 3v56 – hTNFSF-13B extracellular domain + hTNFRSF-13C peptide
    
• Tumor necrosis factor receptor superfamily-13C (BAFF receptor)
  • 1osx – hTNFRSF-13C extracellular domain - NMR
    
  • 2hfg – hTNFL cysteine-rich domain + antibody
    
• Tumor necrosis factor receptor superfamily-14 (LIGHT)
  • 4fhq, 4en0 – hTNFRSF-14 extracellular domain
    
  • 2aw2 – hTNFRSF-14 extracellular domain + B and T lymphocyte attenuator
    
  • 4rsu – hTNFRSF-14 extracellular domain + TNFRSF-14 ligand
    
  • 4kg8 – hTNFSF-14 extracellular domain (mutant)
    
  • 4j6g – hTNFSF-14 extracellular domain + DCR3
    
  • 4kgq, 4kgg – hTNFSF-14 extracellular domain (mutant) + DCR3
    
• Tumor necrosis factor receptor superfamily-16 (nerve growth factor receptor)
  • 4f42, 4f44 – hTNFRSF-16 death domain
    
  • 2n97 – hTNFRSF-16 death domain - NMR
    
  • 1sg1, 3ij2 – hTNFRSF-16 + beta nerve growth factor
    
  • 3buk – hTNFRSF-16 + neurotrophin-3
    
  • 2n80 – hTNFRSF-16 death domain + rho GDP-dissociation inhibitor - NMR
    
  • 2n83 – hTNFRSF-16 death domain + receptor interacting Ser/Thr protein kinase - NMR
    
• Tumor necrosis factor receptor superfamily-17
  • 2kn1 – hTNFRSF-17 extracellular domain - NMR
    
  • 4zfo – hTNFRSF-17 extracellular domain + antibody
    
• Tumor necrosis factor receptor superfamily-18 (GITRL)
  • 4db5 – TNFRSF-18 – rabbit
    
  • 4e4s – TNFRSF-18 – pika
    
  • 4g4f – TNFRSF-18 – bushbaby
    
  • 3fc0, 2qdn, 3b9i – mTNFRSF-18
    
  • 2q1m, 3b93, 3b94 – hTNFRSF-18 extracellular domain
    
  • 2r30, 2r32 – hTNFRSF-18 extracellular domain (mutant)
    
• Tumor necrosis factor receptor superfamily-21 (Dr6)
  • 3u3p, 3u3q, 3u3s, 3u3t, 3u3v – hTNFRSF-21 cysteine-rich domain
    
  • 2dbh – hTNFRSF-21 CARD-like domain - NMR
    
  • 3qo4 – hTNFRSF-21 cysteine-rich domain
    
  • 4yn0 – hTNFRSF-21 cysteine-rich domain + amyloid beta A4 protein