Polyhydroxybutyrate synthase

describing Jmol ^[1] to the rescue.

Function

Polyhydroxybutyrate synthase (PHBS) or PHB synthase catalyze the polymerization of β-hydroxybutyryl coenzyme A to generate polyhydroxybutyrate^[2].

For details see PHB synthase in Rhodobacter sphaeroides.

Relevance

PHB is of interest as bio-derived and biodegradable plastics.

Structural highlights

3D structures of PHB synthase3D structures of PHB synthase

5t6o, 5hz2 - PHBS catalytic domain - Cupriavidus necator

ReferencesReferences

↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
↑ Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 2001 Jan 30;40(4):1011-9. PMID:11170423

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

[2] Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 2001 Jan 30;40(4):1011-9. PMID:11170423

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