Polyhydroxybutyrate synthase

Function

Polyhydroxybutyrate synthase (PHBS) or PHB synthase catalyze the polymerization of β-hydroxybutyryl coenzyme A to generate polyhydroxybutyrate^[1].

For details see PHB synthase in Rhodobacter sphaeroides.

Relevance

PHB is of interest as bio-derived and biodegradable plastics.

Polyhydroxybutyrate synthase catalytic domain complex with glycerol and sulfate (PBD code 5hz2)

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3D structures of PHB synthase3D structures of PHB synthase

5t6o, 5hz2 - PHBS catalytic domain - Cupriavidus necator

ReferencesReferences

↑ Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 2001 Jan 30;40(4):1011-9. PMID:11170423

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Michal Harel

[1] Jia Y, Yuan W, Wodzinska J, Park C, Sinskey AJ, Stubbe J. Mechanistic studies on class I polyhydroxybutyrate (PHB) synthase from Ralstonia eutropha: class I and III synthases share a similar catalytic mechanism. Biochemistry. 2001 Jan 30;40(4):1011-9. PMID:11170423

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